High mitochondrial accumulation of new gadolinium(III) agents within tumour cells.

نویسندگان

  • Daniel E Morrison
  • Jade B Aitken
  • Martin D de Jonge
  • Joseph A Ioppolo
  • Hugh H Harris
  • Louis M Rendina
چکیده

The first bifunctional Gd(III) complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The highest in vitro cellular uptake for any Gd complex reported to date is described, with levels exceeding 10(10) Gd atoms per tumour cell.

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عنوان ژورنال:
  • Chemical communications

دوره 50 18  شماره 

صفحات  -

تاریخ انتشار 2014